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Metolazone is a thiazide-like diuretic marketed under the brand names Zytanix, Metoz, Zaroxolyn, and Mykrox. It is primarily used to treat congestive heart failure and high blood pressure . Metolazone indirectly decreases the amount of water reabsorbed into the bloodstream by the kidney , so that blood volume decreases and urine volume increases.
Metaxalone exhibits increased bioavailability when taken with food. [3] Specifically, in one study, compared to fasted conditions, the presence of food at the time of drug administration increased C max by 77.5%, AUC 0-t by 23.5%, and AUC 0-∞ by 15.4%. [4]
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From or to a drug trade name: This is a redirect from (or to) the trade name of a drug to (or from) the international nonproprietary name (INN).
I'll do my best with the history, although history is notoriously difficult—especially for medical topics, where "history" has a special meaning and severly confounds searches. It's not easy to find information about the development of non-major drugs like metolazone.
The term "thiazide" is also often used for drugs with a similar action that do not have the thiazide chemical structure, such as chlorthalidone, metolazone and indapamide. These agents are more properly termed thiazide-like diuretics. [citation needed] Thiazide diuretics also increase calcium reabsorption at the distal tubule.
A fact from Metolazone appeared on Wikipedia's Main Page in the Did you know column on 25 January 2006. The text of the entry was as follows: Did you know... that metolazone is a medicine used to treat congestive heart failure and hypertension? A record of the entry may be seen at Wikipedia:Recent additions/2006/January. Wikipedia