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Since gestational choriocarcinoma (which arises from a hydatidiform mole) contains paternal DNA (and thus paternal antigens), it is exquisitely sensitive to chemotherapy. The cure rate, even for metastatic gestational choriocarcinoma, is more than 90% when using chemotherapy for invasive mole and choriocarcinoma. [7]
Bone metastasis, or osseous metastatic disease, is a category of cancer metastases that result from primary tumor invasions into bones. Bone-originating primary tumors such as osteosarcoma , chondrosarcoma , and Ewing sarcoma are rare; the most common bone tumor is a metastasis. [ 1 ]
A bone tumor is an abnormal growth of tissue in bone, traditionally classified as noncancerous (benign) or cancerous (malignant). [1] [4] Cancerous bone tumors usually originate from a cancer in another part of the body such as from lung, breast, thyroid, kidney and prostate. [1] There may be a lump, pain, or neurological signs from pressure. [1]
170 Malignant neoplasm of bone and articular cartilage. 170.9 Malignant neoplasm of bone and articular cartilage, site unspecified Ewing's sarcoma; Osteosarcoma; Chondrosarcoma; 171 Malignant neoplasm of connective and other soft tissue. Rhabdomyosarcoma; 172 Malignant melanoma of skin; 173 Other malignant neoplasm of skin; 174 Malignant ...
1956 – Metastatic choriocarcinoma cancer is cured with the antifolate, methotrexate [4] 1956 – First bone marrow transplantation performed by E. Donnall Thomas in order to treat leukemia in one of two identical twins, the healthy twin being the donor [17]
A micrograph showing a choriocarcinoma spread to the lung [13] Choriocarcinomas are exceptionally rare which account for 2.1%-3.4% of all OGCTs. [ 14 ] Under gross examination, the syncytiotrophoblast cells are aligned in a plexiform arrangement with the mononucleated cytotrophoblast cells surrounding the foci of the hemorrhage. [ 1 ]
As microscopic vascular invasion is common in choriocarcinoma, hematogeneous metastasis, especially to the lungs is common. Many choriocarcinomas show extensive hemorrhagic necrosis in the central portion of the tumor; this appears as mixed cystic and solid components at ultrasound.
Gestational choriocarcinoma is a form of gestational trophoblastic neoplasia, which is a type of gestational trophoblastic disease (GTD), that can occur during pregnancy.It is a rare disease where the trophoblast, a layer of cells surrounding the blastocyst, undergoes abnormal developments, leading to trophoblastic tumors.