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Summation, which includes both spatial summation and temporal summation, is the process that determines whether or not an action potential will be generated by the combined effects of excitatory and inhibitory signals, both from multiple simultaneous inputs (spatial summation), and from repeated inputs (temporal summation).
In neurophysiology, the Compound action potential (or CAP) refers to various evoked potentials representing the summation of synchronized individual action potentials generated by a group of neurons or muscle fibers in response to a stimulus. [1]
The gastrocnemius muscle is heterogeneous, composed of both "red" and "pale" muscle, and thus containing fast-twitch high force fibers. Henneman's and colleagues took advantage of the differences between the soleus and gastrocnemius muscles to show that the neurons innervating the soleus muscle:
The compound muscle action potential (CMAP) or compound motor action potential is an electrodiagnostic medicine investigation (electrical study of muscle function). The CMAP idealizes the summation of a group of almost simultaneous action potentials from several muscle fibers in the same area.
Signal transmission from nerve to muscle at the motor end plate. The neuromuscular junction is the synapse that is formed between an alpha motor neuron (α-MN) and the skeletal muscle fiber. In order for a muscle to contract, an action potential is first propagated down a nerve until it reaches the axon terminal of the motor neuron.
The compound muscle action potential (CMAP) size is found using supramaximal stimulation of the motor nerve to the muscle or muscle group (similar to a nerve conduction study). It is recorded using surface electrodes. This is representative of the sum of the surface detected motor unit action potentials from muscles innervated by that nerve.
A neuromuscular junction (or myoneural junction) is a chemical synapse between a motor neuron and a muscle fiber. [1] It allows the motor neuron to transmit a signal to the muscle fiber, causing muscle contraction. [2] Muscles require innervation to function—and even just to maintain muscle tone, avoiding atrophy.
Normal functioning of the central nervous system entails a summation of synaptic inputs made largely onto a neuron's dendritic tree. These local graded potentials, which are primarily associated with external stimuli, reach the axonal initial segment and build until they manage to reach the threshold value. [ 5 ]