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Phenylboronic acid or benzeneboronic acid, abbreviated as PhB(OH) 2 where Ph is the phenyl group C 6 H 5 - and B(OH) 2 is a boronic acid containing a phenyl substituent and two hydroxyl groups attached to boron. Phenylboronic acid is a white powder and is commonly used in organic synthesis.
The general structure of a boronic acid, where R is a substituent.. A boronic acid is an organic compound related to boric acid (B(OH) 3) in which one of the three hydroxyl groups (−OH) is replaced by an alkyl or aryl group (represented by R in the general formula R−B(OH) 2). [1]
2,2-dimethoxypropane and camphorsulfonic acid, and dichloromethane Hydrochloric acid, methanol, water, and ethyl ether Protection of the vicinal diol 2.4 allowed the remaining hydroxyl group in alcohol 2.5 to be selectively oxidized to give aldehyde 2.6. The acetonide was removed much later in the synthesis in preparation for the closure of ring D.
Pinacol is a branched alcohol which finds use in organic syntheses. It is a diol that has hydroxyl groups on vicinal carbon atoms. A white solid that melts just above room temperature, pinacol is notable for undergoing the pinacol rearrangement in the presence of acid and for being the namesake of the pinacol coupling reaction .
It has the formula [(CH 3) 4 C 2 O 2 B] 2; the pinacol groups are sometimes abbreviated as "pin", so the structure is sometimes represented as B 2 pin 2. It is a colourless solid that is soluble in organic solvents. It is a commercially available reagent for making pinacol boronic esters for organic synthesis.
MIDA boronate esters and organotrifluoroborates have both been utilised in "slow release" strategies, in which the reaction conditions are optimised to provide a slow release of boronic acid. This protocol has proved useful in the cross-coupling of some notoriously unstable boronic acids, such as the 2-pyridine boronic acid.
acid (vinegar or citrus juice) a sweetener. a thickener. a dash of salt and pepper. Directions: I combine all the ingredients in a mason jar, shake it vigorously to combine, give it a taste, and ...
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