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In natural and social science research, a protocol is most commonly a predefined procedural method in the design and implementation of an experiment.Protocols are written whenever it is desirable to standardize a laboratory method to ensure successful replication of results by others in the same laboratory or by other laboratories.
In the standard preregistration format, researchers prepare a research protocol document prior to conducting their research. Ideally, this document indicates the research hypotheses, sampling procedure, sample size, research design, testing conditions, stimuli, measures, data coding and aggregation method, criteria for data exclusions, and statistical analyses, including potential variations ...
A clinical trial protocol is a document used to define and manage the trial. It is prepared by a panel of experts. All study investigators are expected to strictly observe the protocol. [citation needed] The protocol describes the scientific rationale, objective(s), design, methodology, statistical considerations and organization of the planned ...
A style guide, or style manual, is a set of standards for the writing and design of documents, either for general use or for a specific publication, organization or field. The implementation of a style guide provides uniformity in style and formatting within a document and across multiple documents.
The use of a sequence of experiments, where the design of each may depend on the results of previous experiments, including the possible decision to stop experimenting, is within the scope of sequential analysis, a field that was pioneered [12] by Abraham Wald in the context of sequential tests of statistical hypotheses. [13]
In a scientific research study or clinical trial, a flaw in the study design or the method of collecting or interpreting information. Biases can lead to incorrect conclusions about what the study or clinical trial showed. (NCI) When a point of view prevents impartial judgment on issues relating to the subject of that point of view.
According to pre-set protocols, these trials can adapt to investigate new hypothesis, and add new endpoints accordingly. An example would be switch from a superiority to a non-inferiority design. Group sequential Sample size, by a set interval at a time. Sample sizes can be changed.
A test method is a method for a test in science or engineering, such as a physical test, chemical test, or statistical test. It is a definitive procedure that produces a test result. [ 1 ] In order to ensure accurate and relevant test results, a test method should be "explicit, unambiguous, and experimentally feasible.", [ 2 ] as well as ...