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At the same time, there is research suggesting that topical terbinafine — though at a hefty concentration of 10%, not the lower 1% found in Lamisil — can effectively kill toenail fungus with a ...
In some cases, WSO is a misdiagnosis of "keratins granulations" which are not a fungus, but a reaction to nail polish that can cause the nails to have a chalky white appearance. A laboratory test should be performed to confirm. [19] Proximal subungual onychomycosis is fungal penetration of the newly formed nail plate through the proximal nail fold.
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Azoles are predominantly fungistatic which inhibit the growth of the fungus instead of killing the fungus. These drugs target the ergosterol biosynthetic pathway by inhibiting the C-14 α-demethylase, a cytochrome P450 enzyme , thus preventing the demethylation of lanosterol to ergosterol which is an essential component of the fungal cell ...
Thymol (also known as 2-isopropyl-5-methylphenol, IPMP), C 10 H 14 O, is a natural monoterpenoid phenol derivative of p-Cymene, isomeric with carvacrol, found in oil of thyme, and extracted from Thymus vulgaris (common thyme), ajwain, [4] and various other plants as a white crystalline substance of a pleasant aromatic odor and strong antiseptic properties.
The fungus was first isolated in 1870 from a tinea cruris patient in Germany by Carl Otto Harz, who named it Acrothecium floccosum. [10] Being unaware of Harz's work, Castellani and Sabouraud identified the species again in 1905 and 1907, respectively, and both placed the fungus into the genus Epidermophyton. [11]
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