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Other side effects include paralysis, resulting in the inability to breathe. [9] If used during pregnancy it may cause permanent deafness in the baby. [9] [1] Amikacin works by blocking the function of the bacteria's 30S ribosomal subunit, making it unable to produce proteins. [9] Amikacin was patented in 1971, and came into commercial use in 1976.
Possible side effects [4] Mechanism of action Aminoglycosides; Amikacin: Amikin: Infections caused by Gram-negative bacteria, such as Escherichia coli and Klebsiella particularly Pseudomonas aeruginosa. Effective against aerobic bacteria (not obligate/facultative anaerobes) and tularemia. All aminoglycosides are ineffective when taken orally as ...
If these drugs are misused or mismanaged, multidrug-resistant TB (MDR-TB) can develop. MDR-TB takes longer to treat with second-line drugs (i.e., amikacin, kanamycin, or capreomycin), which are more expensive and have more side-effects. XDR-TB can develop when these second-line drugs are also misused or mismanaged and become ineffective.
The people identified to be most at risk of major adverse side effects in this study were: age >60, females, HIV positive patients, and; Asians. It can be extremely difficult identifying which drug is responsible for which side effect, but the relative frequency of each is known. [52] The offending drugs are given in decreasing order of frequency:
Taking medications like blood pressure and lipid-lowering drugs for more than 5 years is associated with a lower incidence of dementia, a new study has found.
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Another serious and disabling side effect of aminoglycoside use is vestibular ototoxicity. [19] This leads to oscillopsia (gaze instability) and balance impairments that impact all aspects of an individual's antigravity function. This loss is permanent and can happen at any dose. [21] [22] [23] [24]
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