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Collagen fibers (which provide mechanical stiffness in cartilage) in this region are anchored directly to bones, reducing the possible deformation. Moving closer to soft tissue into the region known as the tidemark, the density of chondrocytes increases and collagen fibers are rearranged to optimize for stress dissipation and low friction. The ...
The articular cartilage extracellular matrix (ECM) has a highly specialized architecture that is zonally organized: the superficial zone consists mostly of collagen II fibers aligned parallel to the articular surface to resist shear forces, whereas the deep zone consists of the same fibers aligned perpendicularly to the bone interface to absorb ...
A sprain is a soft tissue injury of the ligaments within a joint, often caused by a sudden movement abruptly forcing the joint to exceed its functional range of motion.. Ligaments are tough, inelastic fibers made of collagen that connect two or more bones to form a joint and are important for joint stability and proprioception, which is the body's sense of limb position and movem
Collagen cremes are also widely sold even though collagen cannot penetrate the skin because its fibers are too large. [68] Collagen is a vital protein in skin , hair , nails , and other tissues. Its production decreases with age and factors like sun damage and smoking .
Type II collagen is the basis for hyaline cartilage, including the articular cartilages at joint surfaces. It is formed by homotrimers of collagen, type II, alpha 1 chains. It makes up 50% of all protein in cartilage and 85–90% of collagen of articular cartilage.
Cancellous bone or spongy bone, [12] [11] also known as trabecular bone, is the internal tissue of the skeletal bone and is an open cell porous network that follows the material properties of biofoams. [13] [14] Cancellous bone has a higher surface-area-to-volume ratio than cortical bone and it is less dense. This makes it weaker and more flexible.
Collagen, type I, alpha 1, also known as alpha-1 type I collagen, is a protein that in humans is encoded by the COL1A1 gene. COL1A1 encodes the major component of type I collagen , the fibrillar collagen found in most connective tissues , including cartilage .
Dense connective tissue, also called dense fibrous tissue, is a type of connective tissue with fibers as its main matrix element. [1] The fibers are mainly composed of type I collagen. Crowded between the collagen fibers are rows of fibroblasts, fiber-forming cells, that generate the fibers.